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KMID : 0438619930170020101
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Journal of Oral Biology
1993 Volume.17 No. 2 p.101 ~ p.106
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Mineralization of Bone and Osteocalcin Gene Expression
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Kim Gwan-Shik
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Abstract
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Several lines of investigation suggest that osteocatcin, a bone-specific small peptide elaborated by osteoblasts nay play a role in bone formation, resolution and turnever. To provide some informations regarding thr biological function of osteocalcin with respect to mineralization, a culture system for in vitro mineralization has been established initially. Then expression pattern of osteocalcin io cultured osteobtastic cells with tarying degree of mineralization and in calvaria at different stage of development were examined by RNA blot hybridization. During in vitro mineralization, osteocalcin transcripts expression was detectable at the period of matrix mineralization and its level was elevated considerably as mineralization was increasnd. Temporal profile of osteocalcin expression in developing calvaria was cencurrrnt with erpected onset of mineralization. These findings demonstrated that osteocalcin expression is closely related to mineralization though it remains to be determined whether it has a direct role or merely represents a difffrentiation-specific molecule during mineralization.
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